前提要求：Windows 安装Anaconda。

如果没有安装，请参考文章:Windows安装Anaconda使用教程

1、PyQt 5 安装 

在配置python环境的时候需要注意，PyQt5需要python 3.5+以上的版本，在python环境中(conda、pipenv)安装pyqt5相关组件PyQt5以及PyQt5-tools(designer)

pip install pyqt5

pip install pyqt5-tools

# 查看虚拟环境
C:WindowsSystem32>conda env list
# conda environments:
#
base                     D:anaconda3
python310                D:anaconda3envspython310

# 选择虚拟环境
C:WindowsSystem32>activate python310

# conda 自带pyqt5
(python310) C:WindowsSystem32>pip install pyqt5
Requirement already satisfied: pyqt5 in d:anaconda3envspython310libsite-packages (5.15.7)
Requirement already satisfied: PyQt5-sip<13,>=12.11 in d:anaconda3envspython310libsite-packages (from pyqt5) (12.11.0)

# 安装pyqt5-tools 工具
(python310) C:WindowsSystem32>pip install pyqt5-tools
Collecting pyqt5-tools
  Downloading pyqt5_tools-5.15.9.3.3-py3-none-any.whl (29 kB)
Collecting pyqt5==5.15.9
  Downloading PyQt5-5.15.9-cp37-abi3-win_amd64.whl (6.8 MB)
     ---------------------------------------- 6.8/6.8 MB 1.4 MB/s eta 0:00:00
Collecting python-dotenv
  Downloading python_dotenv-1.0.0-py3-none-any.whl (19 kB)
Collecting pyqt5-plugins<5.15.9.3,>=5.15.9.2.2
  Downloading pyqt5_plugins-5.15.9.2.3-cp310-cp310-win_amd64.whl (66 kB)
     ---------------------------------------- 66.8/66.8 kB 3.5 MB/s eta 0:00:00
Collecting click
  Downloading click-8.1.3-py3-none-any.whl (96 kB)
     ---------------------------------------- 96.6/96.6 kB ? eta 0:00:00
Collecting PyQt5-Qt5>=5.15.2
  Downloading PyQt5_Qt5-5.15.2-py3-none-win_amd64.whl (50.1 MB)
     ---------------------------------------- 50.1/50.1 MB 5.0 MB/s eta 0:00:00
Requirement already satisfied: PyQt5-sip<13,>=12.11 in d:anaconda3envspython310libsite-packages (from pyqt5==5.15.9->pyqt5-tools) (12.11.0)
Collecting qt5-tools<5.15.2.2,>=5.15.2.1.2
  Downloading qt5_tools-5.15.2.1.3-py3-none-any.whl (13 kB)
Collecting colorama
  Downloading colorama-0.4.6-py2.py3-none-any.whl (25 kB)
Collecting qt5-applications<5.15.2.3,>=5.15.2.2.2
  Downloading qt5_applications-5.15.2.2.3-py3-none-win_amd64.whl (64.5 MB)
     ---------------------------------------- 64.5/64.5 MB 4.0 MB/s eta 0:00:00
Installing collected packages: PyQt5-Qt5, qt5-applications, python-dotenv, pyqt5, colorama, click, qt5-tools, pyqt5-plugins, pyqt5-tools
  Attempting uninstall: pyqt5
    Found existing installation: PyQt5 5.15.7
    Uninstalling PyQt5-5.15.7:
      Successfully uninstalled PyQt5-5.15.7
Successfully installed PyQt5-Qt5-5.15.2 click-8.1.3 colorama-0.4.6 pyqt5-5.15.9 pyqt5-plugins-5.15.9.2.3 pyqt5-tools-5.15.9.3.3 python-dotenv-1.0.0 qt5-applications-5.15.2.2.3 qt5-tools-5.15.2.1.3

2、 VsCode中安装和配置pyqt插件

1.下载并安装PYQT Integration 插件，搜索PYQT Integration关键字

2. 配置pyqt integration

在插件安装完成后需要进行配置，配置Pyuic和Qtdesigner的文件路径

 Pyuic： 写入pyuic5.exe的完整路径(在python环境目录中搜索此文件，查看目录)

 Qtdesigner： 写入designer.exe的完整路径(在python环境目录中搜索此文件，查看目录)

3 使用PYQT中的Qtdesigner和Pyuic工具

新建一个.ui文件，使用Qtdesigner工具设计界面

 使用Pyuic工具，将讲设计好的ui转换成对应的python代码

 生成了Ui_one.py文件，将.ui文件转换成.py文件。

 4、添加PyQT5程序入口

添加Python 程序入口, main 方法。

# -*- coding: utf-8 -*-

# Form implementation generated from reading ui file 'e:py_workspacepy-qt-demoone.ui'
#
# Created by: PyQt5 UI code generator 5.15.9
#
# WARNING: Any manual changes made to this file will be lost when pyuic5 is
# run again.  Do not edit this file unless you know what you are doing.

import sys
from PyQt5.QtWidgets import QApplication,QMainWindow
from PyQt5 import QtCore, QtGui, QtWidgets


class Ui_MainWindow(object):
    def setupUi(self, MainWindow):
        MainWindow.setObjectName("MainWindow")
        MainWindow.resize(800, 600)
        self.centralwidget = QtWidgets.QWidget(MainWindow)
        self.centralwidget.setObjectName("centralwidget")
        MainWindow.setCentralWidget(self.centralwidget)
        self.menubar = QtWidgets.QMenuBar(MainWindow)
        self.menubar.setGeometry(QtCore.QRect(0, 0, 800, 22))
        self.menubar.setObjectName("menubar")
        MainWindow.setMenuBar(self.menubar)
        self.statusbar = QtWidgets.QStatusBar(MainWindow)
        self.statusbar.setObjectName("statusbar")
        MainWindow.setStatusBar(self.statusbar)

        self.retranslateUi(MainWindow)
        QtCore.QMetaObject.connectSlotsByName(MainWindow)

    def retranslateUi(self, MainWindow):
        _translate = QtCore.QCoreApplication.translate
        MainWindow.setWindowTitle(_translate("MainWindow", "MainWindow"))

if __name__ == '__main__':
    # 只有直接运行这个脚本，才会往下执行
    # 别的脚本文件执行，不会调用这个条件句

    # 实例化，传参
    app = QApplication(sys.argv)

    # 创建对象
    mainWindow = QMainWindow()

    # 创建ui，引用demo1文件中的Ui_MainWindow类
    ui = Ui_MainWindow()
    # 调用Ui_MainWindow类的setupUi，创建初始组件
    ui.setupUi(mainWindow)
    # 创建窗口
    mainWindow.show()
    # 进入程序的主循环，并通过exit函数确保主循环安全结束(该释放资源的一定要释放)
    sys.exit(app.exec_())

执行效果